2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Por um escritor misterioso
Last updated 17 julho 2024
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnature09489/MediaObjects/41586_2010_Article_BFnature09489_Fig1_HTML.jpg)
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-022-05668-z/MediaObjects/41586_2022_5668_Fig1_HTML.png)
mRNA ageing shapes the Cap2 methylome in mammalian mRNA
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://iiif.elifesciences.org/lax/14228%2Felife-14228-fig3-v1.tif/full/,1500/0/default.jpg)
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.mdpi.com/genes/genes-10-00117/article_deploy/html/images/genes-10-00117-g001.png)
Genes, Free Full-Text
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Regulation of antiviral innate immunity by chemical modification of viral RNA - Li - 2022 - WIREs RNA - Wiley Online Library
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://ars.els-cdn.com/content/image/1-s2.0-S2001037021003135-gr1.jpg)
Immune evasion of SARS-CoV-2 from interferon antiviral system - ScienceDirect
Full article: An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond)
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.embopress.org/cms/asset/91e7174f-97a0-48a1-92b5-06d7fdf8c981/embj2022111608-fig-0004-m.jpg)
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.biorxiv.org/content/biorxiv/early/2022/02/03/2022.02.03.478939/F2.large.jpg)
2'-O-methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://europepmc.org/articles/PMC9458431/bin/gkac722fig3.jpg)
2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion. - Abstract - Europe PMC
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.pnas.org/cms/10.1073/pnas.1612444114/asset/ebf56a7d-761a-460e-9a6d-50ac895f1676/assets/graphic/pnas.1612444114sfig01.jpeg)
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.biorxiv.org/content/biorxiv/early/2020/08/16/2020.08.14.251421/F1.large.jpg)
Methylation of RNA Cap in SARS-CoV-2 captured by serial crystallography
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://cdnintech.com/media/chapter/41211/1512345123/media/image7.jpeg)
Messenger RNA Cap Methylation in Vesicular Stomatitis Virus, a Prototype of Non‐Segmented Negative‐Sense RNA Virus
2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.mdpi.com/viruses/viruses-14-01666/article_deploy/html/images/viruses-14-01666-g001.png)
Viruses, Free Full-Text
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Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
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