Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Por um escritor misterioso
Last updated 12 fevereiro 2025
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnchembio.773/MediaObjects/41589_2012_Article_BFnchembio773_Fig1_HTML.jpg)
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.biorxiv.org/content/biorxiv/early/2022/04/13/2021.10.22.465184/F1.large.jpg)
A molecular switch between mammalian MLL complexes dictates
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://pubs.acs.org/cms/10.1021/acs.jmedchem.1c00872/asset/images/large/jm1c00872_0023.jpeg)
Recent Progress of Small Molecule Menin–MLL Interaction Inhibitors
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fleu.2015.144/MediaObjects/41375_2016_Article_BFleu2015144_Fig1_HTML.jpg)
Menin-MLL inhibitors block oncogenic transformation by MLL-fusion
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://onlinelibrary.wiley.com/cms/asset/a99c9776-c1b3-4692-b69e-3d239650f2b3/mfig001.jpg)
Menin as a hub controlling mixed lineage leukemia - Thiel - 2012
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://ars.els-cdn.com/content/image/1-s2.0-S0301472X1630697X-fx1.jpg)
Transcriptional activation by MLL fusion proteins in
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13148-019-0723-0/MediaObjects/13148_2019_723_Fig1_HTML.png)
Co-inhibition of HDAC and MLL-menin interaction targets MLL
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.biorxiv.org/content/biorxiv/early/2022/04/13/2021.10.22.465184/F25.medium.gif)
A molecular switch between mammalian MLL complexes dictates
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs12185-012-1180-0/MediaObjects/12185_2012_1180_Fig3_HTML.gif)
Disordered epigenetic regulation in MLL-related leukemia
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://www.researchgate.net/publication/269182420/figure/fig1/AS:295019396255751@1447349513715/MLL-fusion-proteins-as-targets-for-small-molecule-inhibition-Schematic-diagram-of.png)
MLL fusion proteins as targets for small molecule inhibition
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://file.medchemexpress.com/product_pic/hy-15222.gif)
Menin-MLL inhibitor MI-2 Epigenetic Reader Domain Inhibitor
![Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia](https://onlinelibrary.wiley.com/cms/asset/31336ff9-f649-44eb-bcc7-ed4d41199056/cas15054-fig-0003-m.jpg)
Leukemogenesis via aberrant self‐renewal by the MLL/AEP‐mediated
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