Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Martina MALNAR, PostDoc, PhD

PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is

Marko Košiček - Science communication coordinator - Ruđer Bošković

PDF] Niemann-Pick Type C Disease—Pathophysiology and Future

JCM, Free Full-Text

From genes to hope

Modeling Brain Pathology of Niemann‐Pick Disease Type C Using

Converging pathways in neurodegeneration, from genetics to

The pathogenesis of Niemann–Pick type C disease: a role for

Involvement of the Choroid Plexus in the Pathogenesis of Niemann