Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children, International Journal of Emergency Medicine

Cerebrospinal fluid (CSF) lactate is a potential biomarker for bacterial meningitis in children. To this end, we performed a single-center retrospective cohort study of children from Sao Paulo, Brazil, with CSF pleocytosis to evaluate the ability of CSF lactate to distinguish between children with bacterial and aseptic meningitis. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. We identified 451 children of whom 40 (9%) had bacterial meningitis. Children with bacterial meningitis had a higher median CSF lactate level [9.6 mmol/l, interquartile range (IQR) 3.2-38.5 mmol/l bacterial meningitis vs. 2.0 mmol/l, IQR 1.2-2.8 mmol/l aseptic meningitis]. A CSF lactate cutoff point of 3.0 mmol/l had a sensitivity of 95% [95% confidence interval (CI) 83-99%), specificity of 94% (95% CI 90-96%) and negative predictive value of 99.3% (95% CI 97.7-99.9%) for bacterial meningitis. In combination with a validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and aseptic meningitis in children with CSF pleocytosis.

Correlation glucose/ lactate in the CSF in bacterial meningitis.

Interleukin-6 in cerebrospinal fluid as a biomarker of acute meningitis - Pablo García-Hernández, Belén Prieto, Eduardo Martínez-Morillo, Verónica Rodríguez, Francisco V Álvarez, 2016

Molecules, Free Full-Text

PDF) Meningitis in adult patients with a negative direct cerebrospinal fluid examination: Value of cytochemical markers for differential diagnosis

Promising candidate cerebrospinal fluid biomarkers of seizure disorder, infection, inflammation, tumor, and traumatic brain injury in pediatric patients

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PDF) Predictive Value of Cerebrospinal Fluid Lactate Level for the Diagnosis of Bacterial Meningitis following Cranial Surgery

PDF) Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children

PDF) The diagnostic value of cerebrospinal fluid lactate for post-neurosurgical bacterial meningitis: A meta-analysis

JCDR - Bacterial meningitis, Tuberculous meningitis, Viral meningitis

The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis.

JPM, Free Full-Text

S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version), Neurological Research and Practice

Dilemmas in the diagnosis of acute community-acquired bacterial meningitis - The Lancet

PDF) CSF Lactate -An Independent and Reliable Biomarker among the CSF Parameters to Differentiate Bacterial Meningitis from Aseptic Meningitis