Retrospective evaluation of labetalol as antihypertensive agent in
Por um escritor misterioso
Last updated 04 julho 2024
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Background To evaluate the effect on arterial blood pressure (ABP) of labetalol infusion as treatment for perioperative non nociceptive acute hypertension in dogs. The clinical records of dogs receiving intra or postoperative labetalol infusion were retrospectively reviewed. Invasive systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressure and heart rate (HR) before labetalol infusion (T0) and 15, 30, 45 and 60 min (T1, T2, T3 and T4 respectively) after infusion were retrieved. The dose rate of labetalol infusion and use of concurrently administered drugs that could have potentially affected ABP and/or HR were also recorded. ANOVA for repeated measures and Dunnett’s multiple comparison test were used to determine the effect of labetalol on ABP and HR. Differences were considered significant when p < 0.05. Results A total of 20 dogs met the inclusion criteria, and hypertension was documented after craniotomy (12/20), adrenalectomy (4/20) and other procedures (4/20). Five dogs received labetalol intraoperatively, 14 postoperatively, and 1 during the surgical procedure and recovery. Median infusion duration and rate were 463 (60-2120) minutes and 1.1 (0.2–3.4) mg/kg/h respectively. Median loading dose was 0.2 (0.2–0.4) mg/kg. Labetalol produced a significant decrease in SAP and DAP at all time points compared to T0 (p < 0.05), while the effect was not significant at T1 for MAP (p = 0.0519). Median maximum MAP decrease was 31 (20–90) mmHg. Heart rate did not increase significantly during treatment (p = 0.2454). Acepromazine given before or during labetalol treatment did not reduce significantly ABP (p = 0.735). Conclusions Labetalol produced a reliable and titratable decrease in ABP with non significant increase in HR.
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Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial
![Retrospective evaluation of labetalol as antihypertensive agent in](https://www.aafp.org/content/dam/brand/aafp/pubs/afp/issues/2017/0415/p492-t3.gif)
Severe Asymptomatic Hypertension: Evaluation and Treatment
![Retrospective evaluation of labetalol as antihypertensive agent in](https://journals.sagepub.com/cms/10.1258/om.2012.120010/asset/images/large/10.1258_om.2012.120010-table1.jpeg)
Oral nifedipine versus intravenous labetalol in hypertensive urgencies and emergencies of pregnancy: a randomized clinical trial - B Sathya Lakshmi, Papa Dasari, 2012
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Treatment of Hypertension in the Inpatient Setting: Use of Intravenous Labetalol and Hydralazine - Weder - 2010 - The Journal of Clinical Hypertension - Wiley Online Library
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Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines
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Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial - The Lancet
![Retrospective evaluation of labetalol as antihypertensive agent in](https://d3i71xaburhd42.cloudfront.net/1920e2f781d956b956bf38f6ef525139022c30dc/5-Table2-1.png)
Retrospective review of the use of as-needed hydralazine and labetalol for the treatment of acute hypertension in hospitalized medicine patients
![Retrospective evaluation of labetalol as antihypertensive agent in](https://www.ahajournals.org/cms/asset/10e3bb7e-31ef-442d-aed0-8ce3998b4acf/hypertensionaha.120.15605.fig01.jpg)
Antihypertensive Drugs and Risk of Depression
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A systematic review of nicardipine vs labetalol for the management of hypertensive crises.
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ASSESS BEFORE RX: ADDRESSING THE HARMFUL OVERTREATMENT OF ASYMPTOMATIC HYPERTENSION - SHM Abstracts
![Retrospective evaluation of labetalol as antihypertensive agent in](https://www.mdpi.com/healthcare/healthcare-10-00325/article_deploy/html/images/healthcare-10-00325-g001.png)
Healthcare, Free Full-Text
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Frontiers Management of Blood Pressure During and After Recanalization Therapy for Acute Ischemic Stroke
![Retrospective evaluation of labetalol as antihypertensive agent in](https://bmjopen.bmj.com/content/bmjopen/3/3/e002338/F2.large.jpg)
Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLUE trial
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