Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

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Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?

Temozolomide 85622-93-1 wiki

PDF) Phase I study of temozolomide in paediatric patients with advanced cancer

Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines - Tresch - 2021 - Veterinary Medicine and Science - Wiley Online Library

Temozolomide: -- Mechanism of Action: ----Alkylate/methylate DNA, that

Temozolomide (NSC 362856), DNA Alkylator

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules

Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide‑based glioblastoma chemotherapy