An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf
Por um escritor misterioso
Last updated 17 julho 2024
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/sites/books/NBK581942/bin/obes_historic_drug-Image002.jpg)
The epidemic of obesity cries out for strategies to prevent it, and for treatment when prevention fails. Yet despite the obvious need, the path to developing anti-obesity medications is strewn with failures. This review examines some historical developments in the management of obesity prior to the 20th century followed by more recent efforts to find a “cure.” Since obesity has been a human disease since paleolithic times, discussion of treatment prior to the scientific revolution in about 1500 CE will include comments on treatment of obesity in Grecian Medicine and the Treatment of Sancho “The Fat” King of Leon in 10th century northern Spain. We will then trace treatment trends through time, ending in the early 21st century. In the first half of the 20th century there were 3 main themes associated with drug treatment of obesity: use of thyroid hormones, the interlude with dinitrophenol as drug regulation was beginning to expand, and the introduction of amphetamines and Rainbow Pills. In the second half of the 20th century many new treatment approaches were explored as the scientific basis for understanding regulation of food intake expanded, particularly after the discovery of leptin in 1994. The fact that amphetamine could be addictive led to the search for compounds that acted in the central nervous system with retained the anorectic properties but were not addictive. Both anti-depressant and anticonvulsive drugs were evaluated with disappointing results. The idea of enhancing energy expenditure with thermogenic drugs was pursued but led to a dead end. Peptides, metabolic drugs and drugs that act on the gastrointestinal track are currently under exploration. This chapter makes an effort to answer the question of why it has been so difficult to develop effective medications for the management of obesity. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://pub.mdpi-res.com/applsci/applsci-12-08342/article_deploy/html/images/applsci-12-08342-g001.png?1661331279)
Applied Sciences, Free Full-Text
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/sites/books/NBK278973/bin/clin-prblms-obesity_figure7.jpg)
Clinical Problems Caused by Obesity - Endotext - NCBI Bookshelf
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://pubs.acs.org/cms/10.1021/acs.jafc.8b01770/asset/images/medium/jf-2018-01770v_0005.gif)
Saponins from Sea Cucumber and Their Biological Activities
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/books/NBK278961/bin/exercise-treat-obese-Image001.jpg)
Exercise Treatment of Obesity - Endotext - NCBI Bookshelf
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://img.yumpu.com/10333703/1/500x640/brainwave-entrainment-beginning-guide-osprey-music-inc.jpg)
Brainwave Entrainment Beginning Guide - Osprey Music, Inc.
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.sec.gov/Archives/edgar/data/1955728/000157587223001447/cm406_s1img05.jpg)
cm406_s1img05.jpg
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://blog.priceplow.com/wp-content/uploads/morphogen-nutrition-alphagen-2023-priceplow-tall.png)
Morphogen ALPHAGEN: High-Energy Pre-Workout Updated in 2023
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.sec.gov/Archives/edgar/data/1955728/000157587223001447/cm406_s1img03.jpg)
cm406_s1img03.jpg
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-endotext-lrg.png)
Pharmacologic Treatment of Overweight and Obesity in Adults - Endotext - NCBI Bookshelf
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://patentimages.storage.googleapis.com/01/13/9e/909dde27f6e5d6/US10954259-20210323-C00005.png)
US10954259B1 - Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use - Google Patents
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://www.liebertpub.com/cms/10.1089/thy.2016.0229/asset/images/medium/figure1.gif)
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://tomwademd.net/wp-content/uploads/2023/10/fig1-7.jpg)
Links To And Excerpts From An Updated Approach to Antiobesity Pharmacotherapy: Moving Beyond the 5% Weight Loss Goal - Tom Wade MD
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://i1.rgstatic.net/publication/290446464_Diabetic_Neuropathies/links/5d42f89792851cd04699a7fa/largepreview.png)
PDF) Diabetic Neuropathies
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F978-3-031-26727-7_1/MediaObjects/513436_1_En_1_Fig1_HTML.png)
Pediatric Overweight and Obesity: Basis for an Early Modification of Their Development
![An Historical Review of Steps and Missteps in the Discovery of Anti-Obesity Drugs - Endotext - NCBI Bookshelf](https://journals.physiology.org/cms/10.1152/physrev.00010.2018/asset/images/medium/z9j002192902r001.png)
The Sleep-Immune Crosstalk in Health and Disease
Recomendado para você
-
Rose Bronstein is just one of countless mothers seeking justice for a child lost to cyber abuse. Today, Rose joined Kristin Bride on…17 julho 2024
-
El Greco (Domenikos Theotokopoulos), Portrait of an Old Man17 julho 2024
-
Uncut Gems Directors the Safdie Brothers Are Creating a Comedy17 julho 2024
-
A Look at Recent Changes to the NIL Landscape for Student Athletes17 julho 2024
-
Geometric deep optical sensing17 julho 2024
-
Neal Benowitz, MD Center for Tobacco Control Research and Education17 julho 2024
-
Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain17 julho 2024
-
Bolingbrook Park District News - April / May 2023 Edition by Bolingbrook Park District - Issuu17 julho 2024
-
Bronstein Medicina Diagnóstica - Méier I (Megaunidade), R. Dias da Cruz, Rio de Janeiro - RJ17 julho 2024
-
Bronstein - RM, Já imaginou um exame que pode detalhar todos os tecidos do corpo em imagem, detectar cânceres, mapear a atividade cerebral e, ao contrário do raio-X, não17 julho 2024
você pode gostar
-
Jogo De Tabuleiro Pinguim Neve No Alvo - Multikids17 julho 2024
-
Basic Setup for Your Ring Video Doorbell - Support.com TechSolutions17 julho 2024
-
Pokemon Ultra Sun And Moon Game Download For Android Apk - Colaboratory17 julho 2024
-
Pin en malen17 julho 2024
-
JOGOS DA CHAMPIONS LEAGUE MASCULINA PARA ASSISTIR ONLINE NESSE FIM17 julho 2024
-
File:Log-in on scratch.png - Scratch Wiki17 julho 2024
-
User profile with sad face grey icon. Sad rating, dislike17 julho 2024
-
FNaF: Security Breach in FNaF 4 by MONYAPLAY - Game Jolt17 julho 2024
-
X-Ray Texture Pack for MCPE – Apps no Google Play17 julho 2024
-
complete a nuvem de imagens. copie a imagem e a cor. terminar a17 julho 2024