Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Last updated 15 julho 2024
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.jneurosci.org/content/jneuro/26/27/7151/F1.large.jpg)
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.pnas.org/cms/10.1073/pnas.0408034101/asset/423c4460-cf21-4620-a83a-848a8bc8a7cb/assets/graphic/zpq0010568300001.jpeg)
Fragile X syndrome: (What's) lost in translation?
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.jneurosci.org/content/jneuro/35/41/13836/F1.large.jpg)
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fncomms11020/MediaObjects/41467_2016_Article_BFncomms11020_Fig1_HTML.jpg)
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41380-020-0821-6/MediaObjects/41380_2020_821_Fig4_HTML.png)
Dissociation of functional and structural plasticity of dendritic spines
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrn4001/MediaObjects/41583_2015_Article_BFnrn4001_Fig1_HTML.jpg)
Dysregulation and restoration of translational homeostasis in
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://stemcellsjournals.onlinelibrary.wiley.com/cms/asset/c8c97562-b603-4daf-bf96-2f517adf32ad/stem2505-fig-0006-m.jpg)
Depletion of the Fragile X Mental Retardation Protein in Embryonic
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.frontiersin.org/files/Articles/711446/fcell-09-711446-HTML-r1/image_m/fcell-09-711446-g003.jpg)
Frontiers The Coordination of Local Translation, Membranous
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.researchgate.net/publication/304717559/figure/fig3/AS:379516699594754@1467495240635/Model-showing-involvement-of-FMRP-and-other-FXR-proteins-all-in-blue-associated-with.png)
Model showing involvement of FMRP and other FXR proteins (all in
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fcddis.2017.521/MediaObjects/41419_2017_Article_BFcddis2017521_Fig1_HTML.jpg)
The fragile X mental retardation protein regulates tumor
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://www.frontiersin.org/files/Articles/754485/fpsyt-12-754485-HTML/image_m/fpsyt-12-754485-g001.jpg)
Frontiers The Use of Peptides in the Treatment of Fragile X
![Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond](https://ars.els-cdn.com/content/image/3-s2.0-B9780128001097000200-f20-01-9780128001097.jpg)
Fragile X Syndrome - ScienceDirect
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