PDF] Physiological and molecular basis of extreme radioresistance

The most recent advances in understanding on different aspects of D. radiodurans that are shown to be important for its extraordinary radioresistance are reviewed. Deinococcus radiodurans is characterized for its extraordinary radioresistance. An efficient DNA strandbreak repair and strong oxidative stress tolerance are amongst the mechanisms that contribute to its extreme phenotypes. The multipartite genome structure, recombination repair without RecBC enzymes, absence of SOS response and the roles of serine/ threonine protein kinase in DNA damage response, and the small molecules protecting proteins from oxidative damage are some of the other unique features of this bacterium. Here, we review the most recent advances in our understanding on different aspects of D. radiodurans that are shown to be important for its extraordinary radioresistance.

Frontiers PprI: The Key Protein in Response to DNA Damage in Deinococcus

DivIVA Regulates Its Expression and the Orientation of New Septum Growth in Deinococcus radiodurans

IJMS, Free Full-Text

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

General highlights of radiation response in plants and mammals

Cancers, Free Full-Text

Probing the sORF-Encoded Peptides of Deinococcus radiodurans in Response to Extreme Stress - ScienceDirect

The Function, Underlying Mechanism and Clinical Potential of Exosomes in Colorectal Cancer

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DivIVA Regulates Its Expression and the Orientation of New Septum Growth in Deinococcus radiodurans

Plants, Free Full-Text

The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applications, AMB Express