Molecules, Free Full-Text
Por um escritor misterioso
Last updated 15 julho 2024
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Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, were screened in vitro for their free-radical scavenging and antioxidant capacity in two different assays: ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity fluorescent (ORAC-FL) assays. The most active antioxidants 1 and 8 were further examined to evaluate their neuroprotective properties in vitro. In this study, compound 1 showed a significant neuroprotective effect against the neurotoxin 6-hydroxydopamine in neuroblastoma SH-SY5Y and IMR-32 cell lines. Both compounds also showed prevention from high levels of reactive oxygen species (ROS) in SH-SY5Y cells. Furthermore, the desired monoamine oxidase B (MAO-B) inhibition effect (IC50 = 278 ± 29 nM) for 1 was determined. No toxic effects up to 100 µM of 1 and 8 against neuroblastoma cells were observed. Furthermore, in vivo studies showed that compound 1 demonstrated significant anticonvulsant potential in 6-Hz test, but in neuropathic pain models its antiallodynic and antihyperalgesic properties were not observed. Concluding, the compound 1 seems to be of higher importance as a new phenylalanine-based lead candidate due to its confirmed promise in in vitro and in vivo anticonvulsant activity.
Molecules: The Elements And The Architecture Of Everything
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Angewandte Chemie International Edition - Wiley Online Library
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Molecular biology animated word cloud, t, Stock Video
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Molecules, Free Full-Text
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3D rendering molecule structure. Scientific medical background
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Special 26 Songs Free Zip File - Colaboratory
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Lagu Xiao Wei Get File - Colaboratory
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Atoms & Molecules - Atom Definition, History, Structure of Atom
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Molecules, Free Full-Text
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100,000 Molecules Vector Images
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Adsorption of Zwitterionic Oligomer-grafted Silica Nanoparticles
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Molecules, Free Full-Text
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Molecular biology animated word cloud, t, Stock Video
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Synthesis of Azonia Aromatic Heterocycles Bearing 6–6–6–5–6
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Molecules An Open Access Journal from MDPI
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