A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia - ScienceDirect

Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic strategy for MLL-rearranged (MLL-r) leukemia. Structure-ba…

Disordered epigenetic regulation in MLL-related leukemia

Co-inhibition of HDAC and MLL-menin interaction targets MLL

Synergistic targeting of FLT3 mutations in AML via combined menin

Recent Progress of Small Molecule Menin–MLL Interaction Inhibitors

A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression

ZMYND8-regulated IRF8 transcription axis is an acute myeloid

A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression

Learning from mouse models of MLL fusion gene-driven acute

Novel therapeutic strategies for MLL-rearranged leukemias

Discovery of M-1121 as an Orally Active Covalent Inhibitor of

A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression

MLL::AF9 degradation induces rapid changes in transcriptional

Recent Progress of Small Molecule Menin–MLL Interaction Inhibitors