How does SARS-CoV-2 evade the immune defences?

As most of pathogens, SARS-CoV-2 can be recognized by pattern recognition receptors on innate. Normally, this recognition helps the innate immunity to eliminate the infection or to activate the adaptive immune responses, however, SARS-CoV-2 can use its proteins such as M, N, NSP1 and PLpro to interfere with these pathways.

SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies: Molecular Therapy

Potential Antiviral Immune Response Against COVID-19: Lessons Learned from SARS-CoV

SARS-CoV-2 targets MAVS for immune evasion

Virologica Sinica

Biomedicines, Free Full-Text

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies: Molecular Therapy

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 - ScienceDirect

Innate immune sensing of coronavirus and viral evasion strategies

SARS-CoV-2 cell entry: structural & functional mechanism

IJMS, Free Full-Text