The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

Nifedipine In Pregnancy: Safety, Usage, Dosage And Side Effects

Pharmaceutics, Free Full-Text

LABETALOL HYDROCHLORIDE tablet, film coated

Review of Cardiovascular Drugs in Pregnancy

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial - The Lancet

Full article: Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials

Nutrients, Free Full-Text

Obstetric and Fetal Pharmacology, Article

A COMPARATIVE RANDOMISED CONTROLLED PARALLEL GROUP STUDY OF EFFICACY AND TOLERABILITY OF LABETALOL VERSUS METHYLDOPA IN THE TREATMENT OF NEW ONSET HYPERTENSION DURING PREGNANCY