Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases - ScienceDirect

National Human Genome Research Institute - Female mammals have two X chromosomes in every cell. But one of the X chromosomes is always inactivated, which stops transcription (making RNA), so that there

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Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis

Frontiers X Inactivation and Escape: Epigenetic and Structural Features

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

A schematic diagram of contribution of escape genes to the female bias

X Chromosome Inactivation • iBiology