Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification
Por um escritor misterioso
Last updated 16 julho 2024
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://bioone.org/ContentImages/Journals/ment/59/1/tjab179/graphic/WebImages/img-z12-1_192.jpg)
Arboviruses including dengue, Zika, and chikungunya are amongst the most significant public health concerns worldwide. Arbovirus control relies on the use of insecticides to control the vector mosquito Aedes aegypti (Linnaeus), the success of which is threatened by widespread insecticide resistance. The work presented here profiled the gene expression of Ae. aegypti larvae from field populations of Ae. aegypti with differential susceptibility to temephos originating from two Colombian urban locations, Bello and Cúcuta, previously reported to have distinctive disease incidence, socioeconomics, and climate. We demonstrated that an exclusive field-to-lab (Ae. aegypti strain New Orleans) comparison generates an over estimation of differential gene expression (DGE) and that the inclusion of a geographically relevant field control yields a more discrete, and likely, more specific set of genes. The composition of the obtained DGE profiles is varied, with commonly reported resistance associated genes including detoxifying enzymes having only a small representation. We identify cuticle biosynthesis, ion exchange homeostasis, an extensive number of long noncoding RNAs, and chromatin modelling among the differentially expressed genes in field resistant Ae. aegypti larvae. It was also shown that temephos resistant larvae undertake further gene expression responses when temporarily exposed to temephos. The results from the sampling triangulation approach here contribute a discrete DGE profiling with reduced noise that permitted the observation of a greater gene diversity, increasing the number of potential targets for the control of insecticide resistant mosquitoes and widening our knowledge base on the complex phenotypic network of the Ae. aegypti response to insecticides.
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/355790605/figure/fig4/AS:1084946689073154@1635682856857/Differential-gene-expression-in-the-samples-from-field-susceptible-lab-susceptible-and_Q320.jpg)
PDF) Expansive and Diverse Phenotypic Landscape of Field Aedes
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/317099652/figure/fig2/AS:509204840812544@1498415303021/Model-of-NaCl-and-KCl-excretion-Expression-levels-of-transporters-hypothesized-to-be.png)
Model of NaCl and KCl excretion. Expression levels of transporters
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://d3i71xaburhd42.cloudfront.net/4e5e5e4a7e9d7fa8a4020dde176a1b5a506337cc/6-Table3-1.png)
RNA-Seq Comparison of Larval and Adult Malpighian Tubules of the
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/338482488/figure/fig2/AS:845414794276868@1578574002716/Releases-of-Wolbachia-mosquitoes-with-comparable-levels-of-insecticide-resistance-as.jpg)
Releases of Wolbachia mosquitoes with comparable levels of
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/347232262/figure/fig3/AS:11431281172798160@1688653352419/Genomic-amplification-associated-with-carboxylesterase-over-expression-a.png)
Genomic amplification associated with carboxylesterase over
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://pub.mdpi-res.com/genes/genes-14-01626/article_deploy/html/images/genes-14-01626-g003.png?1692085373)
Genes, Free Full-Text
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/328895163/figure/tbl3/AS:692321473552387@1542073710669/Association-between-selected-P450-gene-SNP-frequency-and-deltamethrin-resistance-in.png)
Association between selected P450 gene SNP frequency and
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://bioone.org/ContentImages/Journals/ment/59/1/tjab179/graphic/img-z10-1_192.jpg)
Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/350007042/figure/fig2/AS:1000443027144706@1615535613699/AdoR-regulated-the-Hsp70-protein-level-and-influenced-the-stress-response-to-paraquat.png)
AdoR regulated the Hsp70 protein level and influenced the stress
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://bioone.org/ContentImages/Journals/ment/59/1/tjab179/graphic/img-z13-1_192.jpg)
Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://ars.els-cdn.com/content/image/1-s2.0-S240593902300045X-ga1.jpg)
One does not simply apply larvicides: Aedes aegypti from
![Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification](https://www.researchgate.net/publication/350765646/figure/fig1/AS:1010915927400448@1618032547124/Cuticle-ultrastructure-by-transmission-electron-microscopy-Legend-Transmission-electron.png)
Cuticle ultrastructure by transmission electron microscopy. Legend
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