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Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are heterogeneous and influenced by metabolic reprogramming of the tumor immune microenvironment (TIME). In the TIME, multiple cell types interact, and the tumor and immune cells compete for limited nutrients, resulting in altered anticancer immunity. Therefore, metabolic reprogramming of individual cell types may influence the outcomes of immunotherapy. Understanding the metabolic competition for access to limited nutrients between tumor cells and immune cells could reveal the breadth and complexity of the TIME and aid in developing novel therapeutic approaches for cancer. In this review, we highlight that, when cells compete for nutrients, the prevailing cell type gains certain advantages over other cell types; for instance, if tumor cells prevail against immune cells for nutrients, the former gains immune resistance. Thus, a strategy is needed to selectively suppress such resistant tumor cells. Although challenging, the concept of cell type-specific metabolic pathway inhibition is a potent new strategy in anticancer immunotherapy.

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Remote immune processes revealed by immune-derived circulating cell-free DNA

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THE CELL : PAUL REVERE11 : Free Download, Borrow, and Streaming : Internet Archive

THE LIVES OF A CELL : LEWIS THOMAS : Free Download, Borrow, and Streaming : Internet Archive

Rapid cell-free forward engineering of novel genetic ring oscillators

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Nature Reviews Molecular Cell Biology on X: From May cover Challenges and directions in studying cell–cell communication by #ExtracellularVesicles @DaveCarter1234 @guillaume_niel @VaderPieter Clayton Lambert & Raposo #EVsAreCool FREE pdf: https

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Cell-free synthesis of human interferon. - Abstract - Europe PMC

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Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation