Cancers, Free Full-Text
Por um escritor misterioso
Last updated 17 julho 2024
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Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.
Journal of Cancer Research and Clinical Oncology
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Cancer-Free, Third Edition by Bill Henderson - Audiobook
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Thoracic Cancer - Wiley Online Library
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Colorectal Cancer Awareness Month Graphics - National LGBT Cancer
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Cancer Free Posters for Sale
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Cell-free nucleic acids as biomarkers in cancer patients
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Destination Healthy Skin Toolkit - The Skin Cancer Foundation
I Am Cancer Free - song and lyrics by ManifesTunes
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Cancer Free Posters for Sale
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PDF) Combination of tumor markers predicts progression and
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MD Anderson Cancer Center: Cancer Treatment & Cancer Research
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