Biology, Free Full-Text
Por um escritor misterioso
Last updated 16 julho 2024
![Biology, Free Full-Text](https://www.mdpi.com/biology/biology-11-01652/article_deploy/html/images/biology-11-01652-g001-550.jpg)
In addition to representing a significant part of the natural background radiation exposure, α-particles are thought to be a powerful tool for targeted radiotherapy treatments. Understanding the molecular mechanisms of recognition, signaling, and repair of α-particle-induced DNA damage is not only important in assessing the risk associated with human exposure, but can also potentially help in identifying ways of improving the efficacy of radiation treatment. α-particles (He2+ ions), as well as other types of ionizing radiation, and can cause a wide variety of DNA lesions, including DNA double-strand breaks (DSBs). In mammalian cells, DNA DSBs can be repaired by two major pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). Here, we investigated their dynamics in mouse NIH-3T3 cells through the recruitment of key proteins, such as the KU heterodimer for NHEJ and RAD51 for HR upon localized α-particle irradiation. To deliver α-particles, we used the MIRCOM microbeam, which allows targeting of subnuclear structures with submicron accuracy. Using mouse NIH-3T3 cells, we found that the KU heterodimer is recruited much earlier at DNA damage sites marked by H2AX phosphorylation than RAD51. We also observed that the difference in the response of the KU complex and RAD51 is not only in terms of time, but also in function of the chromatin nature. The use of a microbeam such as MIRCOM, represents a powerful tool to study more precisely the cellular response to ionizing irradiation in a spatiotemporal fashion at the molecular level.
![Biology, Free Full-Text](http://www.berkeleyreview.com/wp-content/uploads/2021/09/SetPile2022-1-1024x1024.png)
Books - The Berkeley Review
![Biology, Free Full-Text](https://www.beyondachondroplasia.org/content/legacy/2016/08/biology-form-4-chapter-4-chemical-composition-of-the-cell-part-1-13-638.jpg)
Free Full Text] RBM 007 - new approach for achondroplasia - Beyond Achondroplasia
![Biology, Free Full-Text](https://ecdn.teacherspayteachers.com/thumbitem/AP-Biology-Full-Length-Practice-Exam-9058983-1686832911/original-9058983-1.jpg)
AP Biology Full Length Practice Exam by Science Short Stop
![Biology, Free Full-Text](https://biologymajor.wisc.edu/wp-content/uploads/sites/130/2023/04/Meditation-and-Mindfulness-Workshop-for-Biology-Students-791x1024.png)
Meditation & Mindfulness Workshop for Biology Students – April 28, 2023 – Biology Major
![Biology, Free Full-Text](https://i1.sndcdn.com/artworks-HXtTGfT6u3Cs5y4Y-MRnJxQ-t500x500.jpg)
Stream ⚡ Princeton Review AP Biology Premium Prep, 26th Edition: 6 Practice Tests + Complete Conten by Layfieldjunkersfeld
![Biology, Free Full-Text](https://www.vjhemonc.com/wp-content/uploads/2023/04/MDSF-course-1.png)
Advancing MDS Nursing Course 1: Biology, diagnosis and management
![Biology, Free Full-Text](https://external-preview.redd.it/biology-free-full-text-connections-between-diabetes-v0-lCgVVU_Kd6sGk7Hlt2qlrXJYKKHo4FjbGWu8N4q4Ldw.jpg?auto=webp&s=ea316f1425b82e22c5da33459e0fdc0df1a6c2e6)
Biology, Free Full-Text
![Biology, Free Full-Text](https://pub.mdpi-res.com/biology/biology-02-01054/article_deploy/html/images/biology-02-01054-g001-1024.png?1390350638)
Biology, Free Full-Text
A Text-book of Biology for Students in General, Medical and Technical Courses : William Martin Smallwood : Free Download, Borrow, and Streaming : Internet Archive
![Biology, Free Full-Text](https://newshub.sustech.edu.cn/wp-content/uploads/2021/03/WeChat-Image_20210305102044.jpg)
SUSTech Jixian Zhai's group develops protoplasting-free full-length single-nucleus RNA profiling technology in plants - SUSTech · SCHOOL OF LIFE SCIENCES
Biology the easy way : Edwards, Gabrielle I : Free Download, Borrow, and Streaming : Internet Archive
Recomendado para você
-
Baixar club Smart recente 2.2.2 Android APK16 julho 2024
-
Animals, Free Full-Text16 julho 2024
-
Construction of the Azocane (Azacyclooctane) Moiety of the Lycopodium Alkaloid Lycopladine H via an Intramolecular Hydroaminomethylation Strategy16 julho 2024
-
Sustainability, Free Full-Text16 julho 2024
-
IJERPH, Free Full-Text16 julho 2024
-
Final document16 julho 2024
-
Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design - Computational and Structural Biotechnology Journal16 julho 2024
-
Ask Ai Kids Club on the App Store16 julho 2024
-
Team - Soccer, Football, Hockey, Basketball Club & eSport HTML Template by torbara16 julho 2024
-
Synthesis of 3,4,5-Trisubstituted-1,2,4-triazoles16 julho 2024
você pode gostar
-
A/Z」[Aldnoah.ZERO ED 1]16 julho 2024
-
Metal Gear Rising: Revengeance to feature DLC for Metal Gear Solid16 julho 2024
-
V. cholerae proteins present in human stool and recognized16 julho 2024
-
Butterfly - Jogos Online Grátis - Jogos12316 julho 2024
-
Slavia Prague v Rangers16 julho 2024
-
Boneca Disney A Pequena Sereia Transformação 2 Roupas Luxo16 julho 2024
-
The Mighty Quest for Epic Loot: saiba como jogar o novo Action RPG16 julho 2024
-
Wubbox Lyrics 🤖 Playing Krunker Parkour 😎 #fyp #streamer16 julho 2024
-
Five Nights at Freddy's AR - - Android & iOS MODs16 julho 2024
-
I am concerned about the future of Star Wars: Galaxy of Heroes – Star Wars Thoughts16 julho 2024